Are you ready for success? Dogs learn better at Camarillo Canine, where we train dogs and owners to work smarter, better, together. Our goal is excellence, and our program is unlimited, so don't let setbacks slow your stride. Schedule your free consultation today!
Camarillo Canine can get your dog to listen to you anywhere, even around other dogs, cats, people, or food. You will receive a consultation, free start to your training, and temperament evaluation. Let us build a program that will transform your dog's behavior.
We train where you are most comfortable, focusing on efficiency and results.
We can quickly and easily transform your dog's bad behavior and bring balance to your life.
Our programs help you defy distraction, stay safe, and become a leader for your dog.
by Isabel Raposo, Ian C. Fiebelkorn, Jack J. Lin, Josef Parvizi, Sabine Kastner, Robert T. Knight, Assaf Breska, Randolph F. Helfrich
Attention samples visual space sequentially to enhance behaviorally relevant sensory representations. While traditionally conceptualized as a static continuous spotlight, contemporary models of attention highlight its discrete nature. But which neural mechanisms govern the temporally precise allocation of attention? Periodic brain activity as exemplified by neuronal oscillations as well as aperiodic temporal structure in the form of intrinsic neural timescales have been proposed to orchestrate the attentional sampling process in space and time. However, both mechanisms have been largely studied in isolation. To date, it remains unclear whether periodic and aperiodic temporal structure reflect distinct neural mechanisms. Here, we combined computational simulations with a multimodal approach encompassing five experiments, and three different variants of classic spatial attention paradigms, to differentiate aperiodic from oscillatory-based sampling. Converging evidence across behavior as well as scalp and intracranial electroencephalography (EEG) revealed that periodic and aperiodic temporal regularities can theoretically and experimentally be distinguished. Our results extend the rhythmic sampling framework of attention by demonstrating that aperiodic neural timescales predict behavior in a spatially-, context-, and demand-dependent manner. Aperiodic timescales increased from sensory to association cortex, decreased during sensory processing or action execution, and were prolonged with increasing behavioral demands. These results reveal that multiple, concurrent temporal regularities govern attentional sampling.by Anika T. Löwe, Marit Petzka, Maria M. Tzegka, Nicolas W. Schuck
Humans sometimes have an insight that leads to a sudden and drastic performance improvement on the task they are working on. The precise origins of such insights are unknown. Some evidence has shown that sleep facilitates insights, while other work has not found such a relationship. One recent suggestion that could explain this mixed evidence is that different sleep stages have differential effects on insight. In addition, computational work has suggested that neural variability and regularisation play a role in increasing the likelihood of insight. To investigate the link between insight and different sleep stages as well as regularisation, we conducted a preregistered study in which N=90 participants performed a perceptual insight task before and after a 20 minute daytime nap. Sleep EEG data showed that N2 sleep, but not N1 sleep, increases the likelihood of insight after a nap, suggesting a specific role of deeper sleep. Exploratory analyses of EEG power spectra showed that spectral slopes could predict insight beyond sleep stages, which is broadly in line with theoretical suggestions of a link between insight and regularisation. In combination, our findings point towards a role of N2 sleep and aperiodic, but not oscillatory, neural activity for insight.by Macha Dussouchaud, Markel Martinez-Carranza, Pierre-Simon Garcia, Martin Clémancey, Geneviève Blondin, Jean Michel Betton, Ahmed Haouz, Simonetta Gribaldo, Sandrine Ollagnier de Choudens, Ludovic Sauguet, Ariel Mechaly, Frédéric Barras
[Fe-S] clusters are ancient and ubiquitous protein co-factors, which contributed to the emergence of life in an anoxic planet. We have recently identified two minimal [Fe-S] biogenesis systems, MIS and SMS, inferred to be ancestral systems dating back to the Last Universal Common Ancestor and which gave rise to the well-studied modern Iron-Sulfur Cluster (ISC), Nitrogen Fixation (NIF), and Sulfur Mobilization (SUF) machineries. The present study focuses on the ancestor SMS from the hyperthermophilic archaeon Methanocaldococcus jannaschii. Biochemical and structural studies showed that SMS is made of a SmsC2B2 heterotetratmer wherein the SmsC subunit hosts both ATP and [Fe-S] cluster binding sites. Binding of ATP and assembly of [Fe-S] were found to be mutually exclusive allowing for a regulatory coupling between binding of both substrates. Mutagenesis and in vitro transfer experiments revealed the key role of SmsC-contained Cys residues in cluster assembly. Strikingly, the SMS system rescued a non-viable Escherichia coli strain lacking endogenous ISC and SUF systems grown under anoxic conditions, in the presence of Na2S, indicating that sulfide is a source of sulfur for SMS. In addition, we predict that most archaea SmsC proteins hold a similar C-terminal [Fe-S] cluster assembly site. Taking into account those unique structural and functional features, we propose a mechanistic model describing how SmsC2B2 assembles and distributes [4Fe-4S] clusters. Altogether this study established SMS as a new bona fide [Fe-S] biogenesis system that operated in anaerobic prokaryotes prior to evolve to SUF after the Great Oxydation Event.by Valerie J. Rodriguez-Irizarry, Robert W. Maples, Julie K. Pfeiffer
Viruses encounter a range of selective pressures, but inefficiencies during replication can be masked. To uncover factors that limit viral replication, we used forward genetics to enrich for a murine norovirus (MNV) mutant with faster replication. We sequentially harvested the earliest progeny in cultured cells and identified a single amino acid change in the viral NS3 protein, K40R, that was sufficient to enhance replication speed. We found that the NS3-K40R virus induced earlier cell death and viral egress compared with wild-type virus. Mechanistically, NS3-K40R protein disrupted membranes more efficiently than wild-type NS3 protein, potentially contributing to increased mitochondrial dysfunction and cell death. Immunodeficient mice infected with NS3-K40R virus had increased titers, suggesting that increasing egress did not reduce fitness in vivo. Overall, by using a forward genetic approach, we identified a previously unknown inefficiency in norovirus egress and provide new insights into selective pressures that influence viral replication and evolution.by Nick Peoples, Michalis Mihalitsis, Peter C. Wainwright
Innovations often shape the trajectory of macroevolution, yet their effects are usually considered independently, thus ignoring the functional and evolutionary interactions between them. Two innovations that have underpinned the ecological and evolutionary success of ray-finned fishes (Actinopterygii) are large teeth and highly protrusible jaws, which independently expanded the diversity of prey capture strategies. Here, we explore the functional relationship between these innovations across actinopterygians using high-speed videography and phylogenetic comparative methods. We find that these two innovations are functionally and evolutionarily incompatible because there is an overarching tradeoff between jaw protrusion and tooth size. Having large teeth decreases the kinematic diversity of prey capture by restricting species to overtake prey predominantly by swimming, while highly protrusible jaws are only found in species with small teeth. The space within tooth-bearing bones may impose this constraint, by limiting the maximum tooth size of species with gracile jaws adapted for high mobility and jaw protrusion. Nevertheless, some species break this constraint on tooth size through novel adaptations that accommodate exceptionally large teeth, unlocking new feeding modes which may have expanded the nature of aquatic feeding and influenced the ecosystems themselves. Although both high jaw protrusion and large teeth separately expanded prey capture strategies in fishes, they are generally not found in combination and are evolutionarily incompatible.
SAT is a comprehensive dog training curriculum that creates the perfect pet dog and solves common puppy problems!
SAT includes obedience, behavior modification and advanced training. Learn more!
Do you want greater confidence and a better relationship with your dog? Do you want your training to last a lifetime? SAT is your complete animal behavior and training curriculum.
Click a course to learn more.
Minor behavior modifications
Basic includes everything covered in the introductory training.
Basic Behavior Modification (Pulling, Jumping, Barking)
Intermediate includes everything covered in the basic training.
Intermediate Behavior Modification (reactive aggression)
Advanced includes everything covered in the intermediate training.
Advanced Behavior Modification (social aggression)
Dog boarding with Camarillo Canine is an optional opportunity for dogs who require immediate obedience training, rehabilitation, or behavior modification. We take them into boarding and return trained pet dogs.
Boarding duration depends on the skills or behavior problems to be addressed, to be discussed during consultation.
Dogs are boarded with one-to-three other dogs in a home environment. You can view more about our unique facilities online.
Your dog receives training from Camarillo Canine's head trainer during the day.
At night, your dog sleeps indoors in a crate or dog bed.
Please drop your dog off with enough food for the duration of their stay, as well as any medication or special equipment your dog requires.
Owners can visit their boarded dogs any time, provided they notify us 6 hours in advance. This is to ensure your dogs and staff are present and available to meet you.
You exchange emergency contact information when you drop off your dog; you may contact our head trainer with non-emergency questions about your boarded dog during daylight hours.
Here are the 3 most important commands to teach your dog:
Touch, Stay in motion, and Out.Down, Sit and Stand, Heel, Place and Come.Shaping, targeting, luring, and leash cuesMake your dog training last a lifetime
Enjoy any of our advanced lessons. Skills and Training (SAT) students schedule advanced training through the user dashboard.
Camarillo Canine matches the price of any equivalent service.
Cash prices are listed; Contact us for free dog training or financing options.
Dogs learn better together. Whether you want exceptional immersion-based training for your dog, or an ultra-premium home boarding experience, boarding with Camarillo Canine will keep your dog safe, loved, and learning! Learn More.
$240.00 / night
Camarillo Canine makes dog training safe, fun, and fulfilling for you and your dog. We focus on effective and reliable solutions that put your needs first.